• Thelial is dedicated to biological barriers.

    Thelial is exclusively dedicated to improving biological barriers, both to support health and treat disease:

    • Epithelial inflammation diseases
    • Neurodegenerative indications.

    The mechanism of action we exploit is reinforcing biological barriers by targeting the cell polarity machinery.  Thelial focuses on discovery and development of compounds to address mayor unmet market needs.

    theLiTE™ (Thelial – Live Targeted Epithelia) is our proprietary targeted drug discovery platform technology; screening a library of more than 2000 drug candidates we have discovered more than twenty epithelium targeted candidates, validating theLiTE™. Four lead compounds are now being developed further. Please request a non-confidential presentation on out technology and portfolio.

    For more information contact us

theLiTE publication

Together with our strategic partner Cristina Silva Pereira and collaborators we have used platform technology theLiTE to identify promising biological activities in novel secondary metabolites of fungi. The work was published in BMC Genomics in Spring 2016.

PubMed link


Preclinical development ongoing

In an ERC funded preclinical proof-of-concept study we team up with António Jacinto of CEDOC (Nova Medical School) and his group to test the efficacy of selected Thelial drug candidates in two orphan diseases characterised by tight junction defects.


In the News

Lab Times, one of the most popular Life Science journals in Europe, interviewed Thelial's team in fall 2014.

Follow this link to the article →